In the emotional and flamboyant address, he also told guests that he was looking forward to “spending every single day of [his] life with Kim”.
During the lavish open air reception in Florence’s Forte di Belvedere, the Bound 2 singer went on to thank their inner circle for their support.
Referring to everyone on the top table, he said: "We are warriors! There is not one person at this table that has not had to defend us at some point or another.
“At this table…the combination of powers…can make the world a better place.”
The exuberant rapper went on to describe their friends and relatives as "the most remarkable people of our time".
His 20-minute speech also touched on the difficulties of being a celebrity.
"They feel like it’s okay to put you on the tabloid covers to sell your image, to use you in an SNL spoof," he said. "We don’t negotiate. We’re not like that. We’re not stupid." He also added: "The Kardashians are an industry!"
People reported that the wedding party enjoyed their dinner seated at a 224-foot imperial marble table, which had been mounted onto a platform giving magnificent views over Florence.
On the menu was chicken, steak, salmon, tortelloni and both rosé and gold Armand de Brignac Champagne, and the meal was finished off with a white, seven-foot wedding cake that featured fruit layers.
When it was time for the dancing the couple’s friend John Legend took over, serenading them with his hit All of You and Etta James tune At Last.
Before singing he also gave a short – and rather cheeky – speech. It began traditionally enough with him telling the bride and groom that he was "really inspired" by the romantic occasion. He went on: "All these wonderful people here – it’s a celebration of your love.
Then John made a jokey reference to Kanye’s previous romantic conquests, prompting guests to heckle.
“I’ve seen Kanye with other women,’ he said. ‘I’m serious… this is a bad speech but I have never seen him as in to someone as he is in to you Kim.”
“He was so in to you before he was even with you. He is in love with you. I am so happy to see you two together.”