Talking on Inside Edition, the 77-year-old actor said the announcement was "very sad," adding that "something very serious must have happened for Angie to make a decision like this."
Jon explained that he didn't have any insight into the reason behind his daughter's decision to end her marriage to Brad. "I don’t know what it is," he admitted. "It’s a sad thing. Say a little prayer.
"I'm concerned for Angie and the children," he added. "Hopefully I will be seeing them very soon."
As Hello! reported previously, Angelina's lawyer confirmed the shocking split on Tuesday Sept. 20), saying that the actress had filed for "dissolution of marriage" the day before. Robert Offer added that the "decision was made for the health of the family".
"She will not be commenting," Offer continued, "and asks that the family be given its privacy at this time."
According to court documents obtained by TMZ, Angelina asked for physical custody of the couple's six children – Maddox, Pax, Zahara, Shiloh, Vivienne, and Knox, while instructing a judge to allow Brad visitation rights.
The documents also state that the couple have been separated since Sept. 15.
Brad and Angelina married in August 2014. The couple, who met on the set of Mr & Mrs Smith, have been together since 2004.
This is Angelina's third divorce. The 41-year-old actress was previously married to Billy Bob Thornton and Jonny Lee Miller. Brad has endured one previous divorce, having ended his five-year-marriage to Jennifer Aniston in 2005.