See George Clooney's shocked reaction to news of Brad and Angelina's split

It looks like the news of Brad Pitt and Angelina Jolie's split was just as shocking to his best pal, George Clooney, as it was to the rest of the world. When the actor, who is good friends with the couple, was doing an interview at the Leaders Summit on Refugees at the United Nations General Assembly in New York on Tuesday (Sept. 20), he seemed unaware of the breakup.

SCROLL DOWN FOR A VIDEO OF GEORGE'S REACTION

"What happened?" George asked, before being told by a CNN reporter. "I didn't know that. Wow. I feel very sorry them.

TAP TO VIEW FULL GALLERYGeorge Clooney was shocked and saddened by news of Brad Pitt and Angelina Jolie's split

"That's a sad story and unfortunate for a family. It's an unfortunate story about a family. I feel very sorry to hear that." He added: "This is the first I've heard of it."

THE JOLIE-PITTS' LOVE STORY IN PHOTOS

George and Brad became close on the set of Ocean's Eleven in 2001, and went on to star together in the film's two sequels, as well as the 2008 movie Burn After Reading.

Brad and Angelina announced on Tuesday that they were splitting after two years of marriage and an 11-year romance. Angelina filed for divorce on Monday (Sept. 19), citing irreconcilable differences. She has asked for physical custody of the couple's six children – Maddox, Pax, Zahara, Shiloh and twins Vivienne and Knox – and requested that Brad be granted child visitation rights and joint legal custody.

Angelina has requested physical custody of the couple's six children

"This decision was made for the health of the family. She will not be commenting, and asks that the family be given its privacy at this time," her attorney Robert Offer confirmed.

In a statement to People magazine, Brad said: "I am very saddened by this, but what matters most now is the well-being of our kids. I kindly ask the press to give them the space they deserve during this challenging time."

BRAD AND ANGELINA'S SWEETEST KISSES AND CUDDLES

The news has shocked Hollywood – and it didn't take long for Twitter to become a social media soundboard for stars mourning the end of 'Brangelina.'

Chrissy Teigen was among the celebrities who reacted to the divorce announcement

"Brad and Angelina. How am I supposed to go to work today?" Chrissy Teigen wrote, while Charmed actress Alyssa Milano tweeted: "Brad and Angelina?! I'm crushed."

BRAD AND ANGELINA'S MOST LOVING QUOTES

"Is it weird to go pull my kid out of preschool early to tell him Brad and Angelina are splitting?" joked Jenny Mollen, wife of American Pie actor Jason Biggs. Vanderpump Rules star Stassi Schroeder added: "If #Brangelina can't make it, is there really any purpose or meaning of life?"

Boy George took a more reserved standpoint

Others took a more reserved standpoint. "It's sad about Brad and Angelina but it's also none of our business," tweeted musician Boy George.

HELLO! Canada magazine is available for your tablet and smartphone. Get HELLO! Canada, PEOPLE, Vanity Fair and over 100 more of the world’s best magazines for one low monthly price at Texture by Next Issue. CLICK HERE to sign up for a free trial.