Prince Harry, Prince William and William's wife the Duchess of Cambridge, née Kate Middleton, will throw open the doors of Kensington Palace to host the Obamas on Friday 22 April. The royals will treat US President Barack Obama and First Lady Michelle to a private dinner.
The trio are "very much looking forward" to welcoming the politician and his wife, a statement from Kensington Palace read.
It will also be a good chance for the group to reunite, as they have previously seen each other at engagements in the past.
William and Kate last saw the First Lady together in July 2012 at a reception in Buckingham Palace. The Prince also met the President in Washington in 2014 alone.
The first time the couples were introduced to each other was in May 2011 when Barack and Michelle were on a state visit to the UK. William and Kate had just tied the knot a few weeks before and were carrying out one of their first engagements as a married couple.
Prince Harry, meanwhile, spent the day with the Obamas last October as part of his trip to the US. Harry, who was only in the Washington area for one day to promote the 2016 Invictus Games, met wounded military members alongside Michelle.
The First Lady said that she would do whatever she could to "shine a light" on the Invictus Games, which are going to Orlando next month.
Later that afternoon Harry met President Obama for an informal chat in the Oval Office of the White House.
The Obamas will arrive in the UK later this week. On Friday they will also have lunch with the Queen and Prince Philip at Windsor Castle, before their dinner with William, Kate and Harry.
A White House spokesman said: "The visit will allow the president to offer his gratitude to the British government and people for their stalwart partnership with his administration and the American people throughout his presidency."
This will most likely be Barack's final official trip to the UK as President of the United States. He will also hold a joint conference with Prime Minister David Cameron at 10 Downing Street.