His wife, Jamie White Welling, filed official documents on Oct. 16 citing "irreconcilable differences" with the man of steel after 11 years of marriage.
The pair had quietly gone their separate ways in December of last year before making the separation official.
Jamie, a model, is requesting spousal support. The estranged couple do not have any kids together.
The pair met in 1998 in a Miami coffee shop and tied the knot in a romantic Vineyard ceremony four years later. They lived in Vancouver, where Smallville was filmed, for most of their marriage, returning to Los Angeles when the show ended in 2011.
Tom has been keeping a low-profile since the CW series came to an end, but will be appearing alongside Jennifer Garner and Kevin Costner in the movie Draft Day, asports dramedy slated for release next year.