Giuliana Rancic on losing last embryo: 'I think adoption is a beautiful gift'

Giuliana Rancic and husbandBill Rancic have always been candid about their fertility struggles, sharing their experience welcoming a son through surrogacy on their reality series, Giuliana and Bill. In a new interview, the TV personality revealed a recent, heartbreaking loss - despite efforts to give their son, Duke, a sibling, the surrogate carrying the couple's third and final embryo had miscarried on New Year's Eve.

"It was painful," the 40-year-old told People. "We were so optimistic with this last embryo. We thought, 'This is definitely going to work. This is our last shot.'"

CLICK PHOTOS TO ENLARGE: Giuliana Rancic and husband Bill Rancic

Giuliana and Bill welcomed Duke via surrogate in 2012, leaving them with three remaining embryos. Two were successfully implanted into their surrogate in 2014; she sadly miscarried just a few weeks later, but the couple remained hopeful because they still had one embryo left.

Their latest loss " was the toughest blow", Giuliana admitted. "It was a really hard time."

Nevertheless, the Fashion Police star remains hopeful about the possibility of expanding her family. "We are open to everything," she said. "I think adoption is a beautiful gift you're giving each other.

"And it’s funny, I'm even more open to (adoption) than I was before. Because I think to myself, 'I love Duke so much, if I couldn't take care of him, I hope there would be someone else who would love him.'"

Giuliana Rancic with the couple's son Duke

Even if they don’t have another child, Giuliana counts her blessings. " I have to remind myself that I'm very fortunate to have what I have," she previously told People. "It's really about knowing there's a bigger plan at play, so for some reason, it wasn't meant to happen this way. It'll all be clear one day soon."

Getting pregnant herself would be risky for the reality star, who has to take cancer-suppressing medication following her 2011 breast cancer diagnosis, and subsequent double mastectomy. Giuliana and Bill struggled through three gruelling rounds of IVF before her cancer diagnosis – forcing them to put their dreams of starting a family on hold.

The couple opted to use a surrogate and were delighted to welcome son Duke in August 2012.

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